A comparative study of amlexanox and tetracyclines in the management of recurrent aphthous stomatitis

Mohd Zeeshan; Srishti; Sarita Kumari; Yogitha Pothamsetty; Kiran Verma; Tushar Dubey

doi:10.4103/ijpcdr.ijpcdr_34_21

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ORIGINAL ARTICLE

Year : 2021 \| Volume : 8 \| Issue : 4 \| Page : 89-93

A comparative study of amlexanox and tetracyclines in the management of recurrent aphthous stomatitis Mohd Zeeshan¹, Srishti², Sarita Kumari³, Yogitha Pothamsetty⁴, Kiran Verma⁵, Tushar Dubey⁶ ¹ Senior Lecturer, Department of Oral Medicine and Radiology, Kothiwal Dental College, Moradabad, Uttar Pradesh, India ² Senior Lecturer, Department of Oral Medicine and Radiology, Hazaribag College of Dental Sciences and Hospital, Godda, India ³ Private Practitioner, Oral Pathology and Microbiology, Godda, India ⁴ Senior Research Fellow, PGIMER, Chandigarh, India ⁵ Senior Lecturer, Department of Conservative Dentistry and Endodontics, Hazaribag College of Dental Sciences and Hospital, Hazaribagh, Jharkhand, India ⁶ Assistant Professor, SMBT Institute of Dental Sciences and Research, Dhamangaom Nandi Hills, Nasik, Maharastra, India Correspondence Address: Dr. Mohd Zeeshan Department of Oral Medicine and Radiology, Kothiwal Dental College, Moradabad, Uttar Pradesh India Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpcdr.ijpcdr_34_21

Background: Although there are many drugs which are used for topical therapy in recurrent aphthous stomatitis (RAS) patients, there are few clinical trials that have used tetracycline and amlexanox. Aim and Objectives: To evaluated the therapeutic efficacy of topical tetracycline and amlexanox. Materials and Methods: Here in this study we divided the RAS patients into two groups in each group alternative selection was done. Patients of 1st Group received topical application of tetracycline crushed tablets with denture adhesive and few drops of saline solution on each alternative day visit. Same as Group 2nd subject received amlexanox. Treatment response was assessed by measuring pain reduction, photographic record, ulcer duration, and adhesive retention time. Results: Amlexanox oral paste show more efficacy in comparision of topical tetracycline in the treatment of recurrent minor aphthous ulcers. Conculsion: Amlexanox is more effective in comparison of tetracycline.



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